Spencer raced to a 22-2 lead after the first quarter, expanded that to 39-7 at halftime, and took a 63-16 lead into the fourth frame with few substitutions and their veteran starters staying the course to only pad the scoring margin.
Brittany Peterson led the talented Tigers with 20 points, while Ally Mahrt added 16.
Sophomore Liz Dawson paced Cherokee's scoring with five points, while Kelsie Peterson added four, and Taylor Woods and Lynn Carlson three each.
Cherokee sank 13-40 field goals for 33 percent, and cashed in 3-7 free throws. Peterson also led Cherokee in assists with two, and Katie Sambrano, Peterson, Misty Bruhn, and Shelby Dilla registered two osteals each.
"They are a very tough team," said Cherokee coach Abby James. "They're very athletic and deep. Taylor Woods had a good game for us off the bench on the inside. She worked to get open but we had trouble getting her the ball. We're young, we're going to make mistakes.
"A bright spot is that the freshman we called upon stepped up and did a good job in their first varsity competition this year. We'll continue to show improvement."