Spencer mounted an 11-6 lead after the first quarter, but went on a 19-0 scoring tear in the second period to go in at halftime with a 32-13 lead. The Tigers led 56-27 after three quarters, before matching Cherokee basket for basket in the fourth to seal the deal.
Shanon Shaefer led Cherokee's scoring in the two-platoon offense employed by the WHS lasses with 12 points, while Taylor Woods added nine.
Ally Mahrts paced Spencer with 20 points, and Carolyn Gerdeman added 14.
Jackie Wilson led Cherokee on the boards with four rebounds, and Katie Sambrano grabbed three. Shaefer led her team in assists with five, and also in steals with six. Shaefer also was 5-5 from the field, including a three-ball.
A telling factor in the game was Spencer's 25-16 rebounding advantage.
"The girls came out ready to play," said Cherokee coach Abby James. "We played a great first quarter, but struggled during the second quarter. Our fourth quarter was a very aggressive one and the girls were all over the floor, which was great to see.
"As a whole, I'm happy with the way the girls played tonight and hope the enthusiasm continues. I feel we showed tremendous growth tonight."
The Cherokee girls host Hull Western Christian Tuesday night and travel to Spirit Lake Friday before the holiday break.