The potent Tornadoes placed three players in double figures to chart the win, with seniors Slone Masters and Cassie Meylor leading the way with 17 and 16 points, respectively, and sophomore Morgan Vandersloot totaling 14.
The young Cherokee squad was led in scoring by sophomores Shanon Shaefer with nine points, and Katie Sambrano with seven, and senior Julie Miller and sophomore Jackie Wilson with six apiece.
Cherokee sank 13-37 field goals for 35 percent, including 4-12 from the three-point line, and 4-12 free throws.
The winning Tornadoes led in the rebound battle with 22 boards, and Cherokee grabbed 17. Wilson led Cherokee in rebounds with five, and Shaefer and Taylor Woods managed three each.
Shaefer also led in assists with three, and Wilson, Shaefer, and Hummel paced Cherokee in steals with two apiece.
"We moved the ball well in a new offense we hurriedly put together right before the game," said Cherokee coach Heath Hagberg, filling capably in for head coach Abby James who is on maternity leave.
"Storm Lake has played man-to-man defense this year and we learned through the JV game that they were playing a 1-3-1 zone defense, so we adjusted on the fly.
"Our effort was there and the girls worked hard against a very good team. We moved the ball well. Our rebounding and defensive transition needs work, and we need to cut down on turnovers. But I can't fault the effort the girls gave."
Storm Lake led 20-9 after the first quarter, 30-17 at halftime. and 45-25 heading into the final eight minutes.
The busy Cherokee girls host Emmetsburg Tuesday, travel to Spencer Friday, and host Alta Saturday.