Katie Sambrano and Megan Hummel paced Cherokee's scoring with nine points each in the face of Spencer's daunting half-court defensive pressure.
Jackie Wilson added seven points and Megan Carlson six.
Cherokee shot 10-55 from the field for an arctic 18 percent, and was an eye-popping 1-24 from the three-point line. The WHS gals were 11-19 from the free throw line. The Tigers converted 6-13 free throws.
Hummel led Cherokee in rebounding with a dozen, and Liz Dawson grabbed six, and also led her team in steals with four.
"We struggled to get good looks against their tough half court defense and when we got open looks we shot the ball poorly," said Cherokee coach Heath Hagberg.
"Shanon Shaefer (varsity starter) was ill and did not play which caused us some difficulty. I thought we played hard the entire game but struggled on the offensive end with execution."
The Cherokee teams host Spirit Lake Friday night in more Lakes Conference basketball action.