The Wolfpack busted loose from a 26-15 halftime lead to outscore Cherokee 27-6 in the third frame to salt the game away.
Jackie Wilson and Taylor Woods led the Cherokee offense with six points each, and Megan Carlson and Megan Hummel chipped in five points apiece.
The Cherokee girls sank 13-45 field goals against the tall Wolfpack defense for just 29 percent, and were 2-16 for three-balls. Cherokee meshed 2-8 fre throws, compared to 13-21 for HWC.
HWC made 22-73 shots for 30 percent, including 7-29 from the three-point arc.
Megan Hummel led the WHS gals on the boards with eight rebounds, and Katie Sambrano snagged five. Sambrano and Carlson also led the Cherokee club in assists with five each, and Hummel had three steals to lead that category.
"Jackie and Shanon got in early foul trouble and that really hurt us on offense and on the inside," said Cherokee coach Heath Hagberg. "We really need all our guns when we play a ranked team like Western Christian. Taylor did a good job for us off the bench, hitting 3-3 field goals.
"HWC is deep and talented and they lose nothing when they go to their bench. They are tall and they can jump and are very athletic."
Cherokee (0-4) plays at Spirit Lake Tuesday and at undefeated, #2 ranked Estherville-LC Friday.