Cherokee spotted the host Indians a 19-12 lead in the first quarter, and trailed 25-21 at halftime, before holding their own throughout the third quarter to trail 43-40 heading into the final eight minutes.
Efficient Megan Carlson was 2-2 on two-point attempts and 3-6 on three-pointers to lead Cherokee's scoring with 13 points, followed by Shanon Shaefer 12, and Megan Hummel 11.
Cherokee sank 21-44 field goals for a warm 48 percent, including a sizzling 15-28 two-pointers for 54 percent, and converted just 3-13 free throws.
The Indians cashed in 8-11 free throws.
Hummel led a strong rebounding effort for Cherokee with eight rebounds, while Shaefer, Katie Sambrano, and Clare Tuttle grabbed four apiece. Sambrano tallied eight assists in the game, and Carlson registered four. Hummel also led in steals with three.
The Cherokee girls (1-5) take on 6-0 #2 Estherville-LC on the road tonight before entering the holiday break.