Shooting just 32 percent from the field, the Braves landed nobody in double figures, with Eric Wilkie and Stetson Dagel leading the scoring with nine points apiece. Wilkie led his team in assists with six, and Dagel led in rebounds with seven.
Austin Wise paced the host Wolverines with 15 points.
Cherokee sank 13-41 shots for 32 percent, including a 3-11 effort from the three-point line. The Braves were just 3-10 from the foul line.
South O'Brien made 23-58 field goals for 40 percent, and was 4-10 for free throws.
"We struggled getting into a good rhythm offensively," said Cherokee coach Bob Lee. "I think we still had tired legs after Friday night's hard battle against Emmetsburg, and as a result were shooting many of our jumpers short.
"We were pleased with out defensive effort, as South O'Brien can be a very explosive team."
The 3-9 Braves host Alta-Aurelia Thursday night, and travel to Hull Western Christian Friday night.