The visiting Wolverines led 18-11 after the first period, 32-27 at halftime, and went on a 17-6 scoring run in the pivotal third frame to take command.
Matt DeVos paced the winners with 19 points, while Brett Puhrmann added 12. The efficient Wolverines made 21-44 field goals for a warm 48 percent and meshed 15-29 free throws.
Cherokee sank just 14-51 shots for 27 percent, a cold shooting effort usually indicative of tired legs. The Braves made 10-17 free throws.
Stetson Dagel paced the Cherokee scoring with 12 points, while Zac Smith totaled 10, and Marc Husman four. Husman also led his team in rebounds with nine, while Dagel snared eight, and Smith four.
"South O'Brien opened in a man defense against us, and our guys did a real nice job early on of executing our offense, and got us an early lead of 8 to 4 midway through the first quarter," noted Cherokee coach Bob Lee.
"South O'Brien switched to a zone, and I think our tired legs from last night's game against H-M-S showed a little. Shots we normally put in were coming up short. I thought we did a real good job of working through our offense tonight, but we came up a little short in our shooting."
The 0-12 Braves trek to Emmetsburg Friday night for a Lakes Conference tussle.